Lactate and pyruvate metabolism in the exercising ischemic limb.
نویسندگان
چکیده
منابع مشابه
Contracture During Myocardial Ischemia
The effects of inosine (INO) on substrate metabolism and rigor formation in ischemic myocardium were examined in isolated rabbit hearts. Metabolite content was assessed in tissue extracts by chemical analysis and in the whole heart by `C and 31P nuclear magnetic resonance spectroscopy. In ischemic hearts metabolizing either [3-'3Clpyruvate or [1-13C glucose, 1 mM INO increased both total and D3...
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Background The high metabolic activity of the heart makes it particularly suited to the use of hyperpolarized (HP) 13C methods to non-invasively detect and characterize metabolic changes that occur during ischemia/reperfusion (I/R). Energy metabolism in ischemic rat hearts has been previously interrogated with HP 13C-labelled pyruvate ex vivo, and its hyperpolarized metabolites have been imaged...
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BACKGROUND Critical limb ischemia is a chronic pathologic condition defined by the lack of blood flow in peripheral circulation. Microdialysis is a well-known and sensitive method for the early detection of tissue ischemia. The aim of the present study was to use microdialysis in order to analyse cellular metabolism changes after peripheral endovascular revascularization. METHODS Ten patients...
متن کاملEffects of hematocrit on brain metabolism in experimentally induced cerebral ischemia in spontaneously hypertensive rats (SHR).
Brain tissue lactate, pyruvate, and adenosine triphosphate (ATP) were measured 60 min after bilateral carotid ligation in spontaneously hypertensive rats, of which hematocrit (HCT) was varied by exchanging with isovolemic homologous red cells, plasma or whole blood. Supratentorial lactate of the ischemic brain was increased more in high HCT (greater than or equal to 50%) and less in low HCT (30...
متن کامل[Effect of duration of cerebral ischemia on pyruvate dehydrogenase activity (PDH) and metabolites in the gerbil brain].
Pyruvate dehydrogenase (PDH) is one of the mitochondrial enzymes which regulate the glucose metabolism. The purpose of this study is to determine the effect of the duration of cerebral ischemia on PDH activity and the metabolites. Cerebral ischemia was produced by bilateral common carotid artery occlusion in Mongolian Gerbils. 20-minute (1) and 60-minute ischemic groups (2) were made. PDH activ...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 45 6 شماره
صفحات -
تاریخ انتشار 1966